Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT-Reference-Cited by-同舟云学术

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Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT

Published:2024-08-07 Issue:1 Volume:12 Page:
ISSN:2049-3002
Container-title:Cancer & Metabolism
language:en
Short-container-title:Cancer Metab

Author:

Yamauchi Tomoaki,Okano Yumi,Terada Daishu,Yasukochi Sai,Tsuruta Akito,Tsurudome Yuya,Ushijima Kentaro,Matsunaga Naoya,Koyanagi Satoru,Ohdo Shigehiro

Funder

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1186/s40170-024-00352-4.pdf

Reference52 articles.

1. Faubert B, Solmonson A, DeBerardinis RJ. Metabolic reprogramming and cancer progression. Science 2020;368.

2. Yang F, Hilakivi-Clarke L, Shaha A, Wang Y, Wang X, Deng Y, et al. Metabolic reprogramming and its clinical implication for liver cancer. Hepatology. 2023;78:1602–24.

3. Cha YJ, Kim ES, Koo JS. Amino acid transporters and glutamine metabolism in breast cancer. Int J Mol Sci 2018;19.

4. Lieu EL, Nguyen T, Rhyne S, Kim J. Amino acids in cancer. Exp Mol Med. 2020;52:15–30.

5. Butler M, van der Meer LT, van Leeuwen FN. Amino acid depletion therapies: starving cancer cells to death. Trends Endocrinol Metab. 2021;32:367–81.

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