Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities-Reference-Cited by-同舟云学术

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Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities

Published:2018-04-17 Issue:1 Volume:6 Page:
ISSN:2049-3002
Container-title:Cancer & Metabolism
language:en
Short-container-title:Cancer Metab

Author:

Garrett Matthew,Sperry Jantzen,Braas Daniel,Yan Weihong,Le Thuc M.,Mottahedeh Jack,Ludwig Kirsten,Eskin Ascia,Qin Yue,Levy Rachelle,Breunig Joshua J.,Pajonk Frank,Graeber Thomas G.,Radu Caius G.,Christofk Heather,Prins Robert M.,Lai Albert,Liau Linda M.,Coppola Giovanni,Kornblum Harley I.

Funder

National Institutes of Health

UCLA SPORE in Brain Cancer

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

American Cancer Society

NINDS Informatics Center for Neurogenetics and Neurogenomics

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

Link

http://link.springer.com/content/pdf/10.1186/s40170-018-0177-4.pdf

Reference48 articles.

1. King A, Selak MA, Gottlieb E. Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene. 2006;25(34):4675–82.

2. Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008;321(5897):1807–12.

3. Lai A, Kharbanda S, Pope WB, Tran A, Solis OE, Peale F, Forrest WF, Pujara K, Carrillo JA, Pandita A, et al. Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J Clin Oncol. 2011;29(34):4482–90.

4. Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462(7274):739–44.

5. Turcan S, Rohle D, Goenka A, Walsh LA, Fang F, Yilmaz E, Campos C, Fabius AW, Lu C, Ward PS, et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012;483(7390):479–83.

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