Author:
Wang Yi,Wang Lin,Yang Zeyong,Chen Fang,Liu Zhiwei,Tang Zheng
Abstract
Abstract
Background
Hypospadias is one of the most common male congenital malformations worldwide. It is characterised by the abnormal positioning of the opening of urethra, and may lead to problems with urination and sexual function. Various factors were suggested to contribute to hypospadias pathogen. This study aimed to evaluate the relationship between perinatal factors and neonatal hypospadias based on a large sample of male newborns.
Methods
This retrospective case–control study was conducted at the International Peace Maternal and Child Health Hospital, Shanghai Jiao Tong University School of Medicine. Male infants with hypospadias (N = 97) and without any birth defects (N = 42,147) who were born in January 2015 to December 2019 were enrolled in this study. A statistical analysis of perinatal factors, such as maternal age, primiparity, multiple births, hypertensive disorders of pregnancy (HDP), diabetes mellitus (DM), placenta previa, thyroid diseases, hepatitis B, obesity, meconium-stained amniotic fluid, gestational age, low birth weight (LBW), small for gestational age (SGA) and in vitro fertilization (IVF) was used to assess the risk factors for hypospadias.
Results
The overall incidence of hypospadias in male infants was 0.23% (97/42,244). The univariate analysis of potential risk factors for hypospadias showed that HDP, primiparity, multiple births, hyperthyroidism, preterm delivery, LBW and SGA had a statistical association with hypospadias. After adjusting for potential confounders in a multivariate regression analysis, the odds ratios (OR) and 95% confidence intervals (CI) were calculated for the following risk factors for hypospadias: HDP (OR: 3.965, 95% CI: 2.473–6.359, P < 0.01), multiple births (OR: 2.607, 95% CI: 1.505–4. 514, P < 0.01) and hyperthyroidism (OR:4.792, 95% CI: 1.700–13.506, P < 0.01), which suggested these factors were significant independent risk factors for hypospadias.
Conclusions
Perinatal factors, such as HDP, multiple births and hyperthyroidism may be associated with hypospadias in male infants.
Funder
Program of Shanghai Academic Research Leader
National Natural Science Foundation of China
Interdisciplinary Program of Shanghai Jiao Tong University
Clinical Research Plan of Shanghai Hospital Development Center
Shanghai Municipal Science and Technology Major Project
Publisher
Springer Science and Business Media LLC
Subject
Obstetrics and Gynecology
Cited by
5 articles.
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