Abstract
Abstract
Background
Vitamin D deficiency is a global public health issue in women and children and is associated with adverse impacts on child growth, such as rickets. However, prior studies have mainly focused on measuring vitamin D levels in singleton pregnant women and their offspring, and very limited studies have revealed the prevalence of vitamin D deficiency in twin pregnant women and their offspring. The aim of this study was to investigate vitamin D levels in twin-pregnant women and their neonates. We also explored the correlation of maternal vitamin D levels with neonatal outcomes and infant growth.
Methods
A prospective subcohort investigation was carried out among 72 dichorionic, diamniotic twin-pregnant mothers and their twin offspring from the Longitudinal Twin Study. Peripheral blood was collected from the mothers in the third trimester, and cord blood was collected from neonates at birth to identify 25[OH]D levels. Data on the characteristics of the mothers and neonates were collected. Infant growth data and food sensitivities were also collected.
Results
The average maternal 25[OH]D level was 31.78 ng/mL, with 19.4% being deficient and 20.8% insufficient, while the average neonatal 25[OH]D level was 15.37 ng/mL, with 99.3% being deficiency or insufficient. A positive correlation was found between maternal and neonatal 25[OH]D levels (beta-value: 0.43, 95% CI: 0.37, 0.49). Interestingly, the higher the maternal 25[OH]D level was, the smaller the cotwin birthweight discordance (beta-value: -2.67, 95% CI: − 5.11, − 0.23). In addition, the infants of mothers with vitamin D deficiency were more likely to be allergic to foods at 6 months than those of mothers with vitamin D sufficiency.
Conclusions
Twin neonates were at high risk of vitamin D deficiency, although their mothers’ vitamin D deficiency partially improved. Higher maternal vitamin D levels were associated with smaller discordance of cotwin birthweight.
Trial registration
Chinese Clinical Trial Registry ChiCTR-OOC-16008203, 1st April 2016.
Funder
Key Technologies Research and Development Program
National Natural Science Foundation of China
Chongqing Science and Technology Commission
NHC Key Laboratory of Birth Defects and Reproductive Health
Publisher
Springer Science and Business Media LLC
Subject
Obstetrics and Gynaecology
Reference44 articles.
1. Foger-Samwald U, Dovjak P, Azizi-Semrad U, Kerschan-Schindl K, Pietschmann P. Osteoporosis: pathophysiology and therapeutic options. EXCLI J. 2020;19:1017–37.
2. Scheffer-Rath ME, Boot AM. The many facets of vitamin D in the pediatric population. Pediatr Endocrinol Rev. 2020;17(4):293–301.
3. Al Mheid I, Quyyumi AA. Vitamin D and cardiovascular disease: controversy unresolved. J Am Coll Cardiol. 2017;70(1):89–100. https://doi.org/10.1016/j.jacc.2017.05.031.
4. Hussain Gilani SY, Bibi S, Siddiqui A, Ali Shah SR, Akram F, Rehman MU. Obesity and diabetes as determinants of vitamin D deficiency. J Ayub Med Coll Abbottabad. 2019;31(3):432–5.
5. Khalil I, Barma P. Subcontinental atmosphere and inherent immune system may have impact on novel Corona Virus’ 2019 (nCovid-19) prevalence in South East Asia. Mymensingh Med J. 2020;29(2):473–80.
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