Author:
Kyozuka Hyo,Murata Tsuyoshi,Fukuda Toma,Yamaguchi Akiko,Kanno Aya,Yasuda Shun,Sato Akiko,Ogata Yuka,Kuse Masahito,Hosoya Mitsuaki,Yasumura Seiji,Hashimoto Koichi,Nishigori Hidekazu,Fujimori Keiya,Kamijima Michihiro,Yamazaki Shi,Ohya Yukihiro,Kishi Reiko,Yaegashi Nobuo,Hashimoto Koichi,Mori Chisato,Ito Shuichi,Yamagata Zentaro,Inadera Hidekuni,Nakayama Takeo,Iso Hiroyasu,Shima Masayuki,Kurozawa Youichi,Suganuma Narufumi,Kusuhara Koichi,Katoh Takahiko,
Abstract
Abstract
Background
Determining the appropriate preconception care to reduce the occurrence of hypertensive disorder of pregnancy (HDP) remains a challenge in modern obstetrics. This study aimed to examine the association between pre-pregnancy calcium (Ca) intake and HDP in normotensive primiparas.
Methods
We used data from the Japan Environment Children’s study (JECS), which is the largest birth cohort study. A total of 33,894 normotensive Japanese primiparas were recruited for JECS between January 2011 and March 2014. Participants were categorized into five groups according to pre-pregnancy Ca intake quintiles (Q1 and Q5 were the lowest and highest Ca intake groups, respectively) to compare their basic background and obstetrics outcome. Multiple logistic regressions were performed to identify the effect of pre-pregnancy Ca intake on HDP, early onset HDP, and late-onset HDP, using Ca intake thresholds of 500, 550, 650, 700, 1000, 1500, and 1500 mg.
Results
We found significant differences in maternal background among the Ca intake groups; in particular, there were more participants with low socioeconomic status, indicated by low education level and low household income, and smokers in the lowest Ca intake group. Multiple logistic regression did not show any significant difference with regard to HDP, early onset HDP, and late-onset HDP in each Ca intake threshold.
Conclusions
Despite considerable recommendations concerning Ca intake for women of reproductive age, the present study indicates that pre-pregnancy Ca intake was not associated with an increased risk of new-onset hypertension among primiparas during pregnancy. Further studies examining the effect of other pre-pregnancy dietary factors on obstetric outcomes should be considered in the formulation of earlier preventive strategies for primiparas.
Publisher
Springer Science and Business Media LLC
Subject
Obstetrics and Gynecology