Author:
Shalaby Mohamed A.,Maged Ahmed M.,Al-Asmar Amira,El Mahy Mohamed,Al-Mohamady Maged,Rund Nancy Mohamed Ali
Abstract
Abstract
Background
Objective to assess the value of preoperative tranexamic acid (TXA) in reduction of intraoperative and postoperative blood loss in high-risk cesarean delivery (CD).
Methods
A double blind randomized controlled trial included 160 high risk women who underwent elective lower segment CD. They were equally randomized to receive either 1 g of TXA or placebo 15 min before surgery. The primary outcome was Intraoperative blood loss.
Results
The estimated blood loss was significantly higher in the placebo group when compared to TXA group (896.81 ± 519.6 vs. 583.23 ± 379.62 ml, P < 0.001).
Both postoperative hemoglobin and hematocrit were lower (9.2 ± 1.6 and 27.4 ± 4.1 vs. 10.1 ± 1.2 and 30.1 ± 3.4, P values < 0.001and 0.012 respectively) and their change percentages (15.41 vs. 7.11%, P < 0.001) were higher in the placebo group when compared to TXA one.
The need for further ecbolics was higher in placebo group when compared to TXA group (46.25 vs. 13.75%, P < 0.001).
Conclusion
Preoperative TXA is safe and effective in reducing blood loss during and after high-risk CD.
Trial registration
ClincalTrial.gov ID: NCT03820206.
Publisher
Springer Science and Business Media LLC
Subject
Obstetrics and Gynecology
Cited by
8 articles.
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