Genomic characterization of peste des petits ruminants vaccine seed “45G37/35-k”, Russia
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Published:2022-10-08
Issue:1
Volume:53
Page:
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ISSN:1297-9716
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Container-title:Veterinary Research
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language:en
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Short-container-title:Vet Res
Author:
Kwiatek Olivier, Libeau Geneviève, Guendouz Samia, Corbanini Chloé, Gogin Andrey, Lunitsin Andrey, Sindryakova Irina, Koblasov Denis, Bataille ArnaudORCID
Abstract
AbstractProduction of peste des petits ruminants (PPR) vaccines in Russia is based on two attenuated virus strains (“45G37/35-k” and “ARRIAH”) of common origin. Here, the identity of the strain PPRV/45G37/35-k was investigated using a full genome, Illumina deep sequencing approach. Phylogenomic analysis showed that PPRV/45G37/35-k belongs to the same lineage as the widely used PPRV vaccine strain Nigeria/75/1 (lineage II). However, 248 nucleotide differences separate the genomes of these vaccine strains, indicating that the PPRV vaccine strains produced in Russia are new strains not yet recognised by the World Organization for Animal Health (WOAH). Detailed information on the safety and efficacy of these vaccines should be provided to the WOAH before further national and international distribution.
Publisher
Springer Science and Business Media LLC
Subject
General Veterinary
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