Abstract
AbstractInference and analysis of gene regulatory networks (GRNs) require software that integrates multi-omic data from various sources. The Network Zoo (netZoo; netzoo.github.io) is a collection of open-source methods to infer GRNs, conduct differential network analyses, estimate community structure, and explore the transitions between biological states. The netZoo builds on our ongoing development of network methods, harmonizing the implementations in various computing languages and between methods to allow better integration of these tools into analytical pipelines. We demonstrate the utility using multi-omic data from the Cancer Cell Line Encyclopedia. We will continue to expand the netZoo to incorporate additional methods.
Funder
National Heart, Lung, and Blood Institute
National Cancer Institute
National Human Genome Research Institute
American Lung Association
Norwegian research council
Norwegian Cancer Society
German Federal Ministry of Education and Research
Publisher
Springer Science and Business Media LLC
Cited by
10 articles.
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