Author:
Foffa Ilenia,Festa Pier Luigi,Ait-Ali Lamia,Mazzone Annamaria,Bevilacqua Stefano,Andreassi Maria Grazia
Abstract
Abstract
The bicuspid aortic valve (BAV) and specific systemic autoimmune diseases are associated with cardiovascular manifestation, including aortic aneurysm. We reported a case of 64 year-old patient with BAV and a history of ankylosing spondylitis (AS) and systemic lupus erythematosus (SLE), and who developed ascending thoracic aortic aneurysm. The patient presented also the homozygosity for genetic variants of MMP9, ACE, MTHFR and PAI-1 genes. Gene-environmental interactions may represent an additional pathogenetic dimension in the still challenging management of the abnormalities of the aortic wall, including dilatation, aneurysm and dissection.
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine,Radiology Nuclear Medicine and imaging,General Medicine
Reference6 articles.
1. Friedaman T, Mani A, Elefteriades JA: Bicuspid aortic valve: clinical approach and scientific review of a common clinical entity. Expert Rev Cardiovasc Ther 2008, 6: 235-4. 10.1586/14779072.6.2.235
2. Chang WL, Huang CM, Yang YH, Lin YT, Chiang BL: Aortic aneurysm in systemic lupus erythematosus. J Microbiol Immunol Infect 2004, 37: 310-2.
3. Palazzi C, D' Angelo S, Lubrano E, Olivieri I: Aortic involvement in ankylosing spondylitis: A Review. Clin Exp Rheumatol 2008, 26: S131-4.
4. Thompson AR, Drenos F, Hafez H, Humphries SE: Candidate gene association studies in abdominal aortic aneurysm disease: a review and meta-analysis. Eur J Vasc Endovasc Surg 2008, 35: 19-30. 10.1016/j.ejvs.2007.07.022
5. Jones K, Powell J, Brown L, Greenhalgh R, Jormsjö S, Eriksson P: The influence of 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene promoter on the incidence, growth and operative risk of abdominal aortic aneurysm. Eur J Vasc Endovasc Surg 2002, 23: 421-5. 10.1053/ejvs.2002.1633
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