Abstract
Abstract
Background
Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events.
Case presentation
We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib who presented with a rapidly growing thyroid nodule and dysphonia. An acute invasive fungal infection was identified on a core needle biopsy; mucormycosis was confirmed on culture. The patient was successfully treated with surgical debridement and long-term antifungal therapy.
Conclusion
Patients on ibrutinib may be at risk of acute invasive fungal infections of the head and neck.
Publisher
Springer Science and Business Media LLC
Subject
Otorhinolaryngology,Surgery
Reference10 articles.
1. Ghez D, Calleja A, Protin C, Baron M, Ledoux M, Damaj G. Dupont et al. early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib. Blood. 2018;131(17):1955–9.
2. Kreiniz N, Bejar J, Polliack A, Tadmor T. Severe pneumonia associated with ibrutinib monotherapy for CLL and lymphoma. Hematol Oncol. 2018;36:349–54.
3. Stein MK, Karri S, Reynolds J, et al. Cutaneous Mucormycosis following a bullous Pemphigoid flare in a chronic lymphocytic leukemia patient on Ibrutinib. World J Oncol. 2018;9(2):62–5.
4. Prasad N, Manjunath R, Bhadauria D, et al. Mucormycosis of the thyroid gland: a cataclysmic event in renal allograft recipient. Indian J Nephrol. 2018;28(3):232–5.
5. Irga N, Kosiak W, Jaworski R, Komarnicka J, Birkholz D. Hyperthyroidism secondary to disseminated mucormycosis in a child with acute lymphoblastic leukemia: case report and a review of published reports. Mycopathologia. 2012;175(1–2):123–7.
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献