Abstract
Abstract
Background
Close margins influence treatment and outcome in patients with oral squamous cell carcinoma (OSCC). This study evaluates 187 cases of surgically treated OSCC regarding the impact of close margins on recurrence-free survival (RFS) and disease-specific survival (DSS).
Methods
Predictors of worsened outcome were identified using Kaplan-Meier analysis and multivariate Cox regression analysis.
Results
Tumour size [HR:1.70(0.95–3.08)], nodal status [HR:2.15(1.00–4.64)], presence of extracapsular spread (ECS) [HR:6.36(2.41–16.74)] and smoking history [HR:2.87(1.19–6.86)] were associated with worsened RFS. Similar factors were associated with worsened DSS. Close margins did not influence RFS or DSS.
Conclusions
While most conventional risk factors for OSCC conferred a worsened outcome, close margins did not. One explanation for this would be that close margins (< 5 mm) are equivalent to clear margins and the cutoff definition for a close margin should be re-evaluated. Lack of standardized pathology could also reduce accuracy of reporting of close surgical margins.
Graphical abstract
Publisher
Springer Science and Business Media LLC
Subject
Otorhinolaryngology,Surgery
Reference34 articles.
1. Binahmed A, Nason RW, Abdoh AA. The clinical significance of the positive surgical margin in oral cancer. Oral Oncol. 2007;43(8):780–4.
2. Chen T-C, Wang C-P, Ko J-Y, Yang T-L, Lou P-J. The impact of pathologic close margin on the survival of patients with early stage oral squamous cell carcinoma. Oral Oncol. 2012;48(7):623–8.
3. Kurita H, Nakanishi Y, Nishizawa R, Xiao T, Kamata T, Koike T, et al. Impact of different surgical margin conditions on local recurrence of oral squamous cell carcinoma. Oral Oncol Pergamon. 2010;46(11):814–7.
4. Nason RW, Binahmed A, Pathak KA, Abdoh AA, Sándor GKB. What is the adequate margin of surgical resection in Oral cancer? Oral surgery, Oral medicine, Oral pathology, Oral radiology, and Endodontology. Mosby. 2009;107(5):625–9.
5. Thomas J, Ow JNM. Current Management of Advanced Resectable Oral Cavity Squamous Cell Carcinoma. Clin Exp Otorhinolaryngol7 ed. Korean Society of Otorhinolaryngology - Head and Neck Surgery. 2011;4(1):1–10.
Cited by
18 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献