Abstract
Abstract
Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. Treatment regimens and outcomes vary widely in the literature and no clear protocol exists. This manuscript describes a patient with CAD who developed severe ischemia of the nose that resolved completely without sequellae following a medical regimen of aspirin, low molecular weight heparin, nitroglycerin ointment and hyperbaric oxygen therapy (HBOT). To our knowledge, this is the first reported case where nitroglycerin ointment or HBOT was successfully employed in the treatment of this complication.
Publisher
Springer Science and Business Media LLC
Subject
Otorhinolaryngology,Surgery
Reference20 articles.
1. Swiecicki PL, Hegerova LT, Gertz MA. Cold agglutinin disease. Blood. 2013;122(7):1114–21.
https://doi.org/10.1182/blood-2013-02-474437
.
2. Gregory GP, Farrell A, Brown S. Cold agglutinin disease complicated by acrocyanosis and necrosis. Ann Hematol. 2017;96(3):509–10.
https://doi.org/10.1007/s00277-016-2905-6
.
3. Mitchell AB, Pergrum GD, Gill AM. Cold agglutinin disease with Raynaud's phenomenon. Proc R Soc Med. 1974;67(2):113–5.
4. Poldre P, Pruzanski W, Chiu HM, Dotten DA. Fulminant gangrene in transient cold agglutinemia associated with Escherichia coli infection. Can Med Assoc J. 1985;132(3):261–3.
5. Oh SH, Kim DS, Ryu DJ, Lee KH. Extensive cutaneous necrosis associated with low titres of cold agglutinins. Clin Exp Dermatol. 2009;34(7):e229–30.
https://doi.org/10.1111/j.1365-2230.2008.03078.x
.