Author:
Park Subin,Yi Ki Kyoung,Na Riji,Lim Ahyoung,Hong Jin Pyo
Abstract
Abstract
Background
Previous research on serum total cholesterol and suicidality has yielded conflicting results. Several studies have reported a link between low serum total cholesterol and suicidality, whereas others have failed to replicate these findings, particularly in patients with major affective disorders. These discordant findings may reflect the fact that studies often do not distinguish between patients with bipolar and unipolar depression; moreover, definitions and classification schemes for suicide attempts in the literature vary widely.
Methods
Subjects were patients with one of the three major psychiatric disorders commonly associated with suicide: schizophrenia, bipolar affective disorder, and major depressive disorder (MDD). We compared serum lipid levels in patients who died by suicide (82 schizophrenia, 23 bipolar affective disorder, and 67 MDD) and non-suicide controls (200 schizophrenia, 49 bipolar affective disorder, and 175 MDD).
Results
Serum lipid profiles did not differ between patients who died by suicide and control patients in any diagnostic group.
Conclusions
Our results do not support the use of biological indicators such as serum total cholesterol to predict suicide risk among patients with a major psychiatric disorder.
Publisher
Springer Science and Business Media LLC
Subject
Behavioral Neuroscience,Biological Psychiatry,Cognitive Neuroscience,General Medicine
Cited by
32 articles.
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