Author:
Eisener-Dorman Amy F,Grabowski-Boase Laura,Tarantino Lisa M
Abstract
Abstract
Background
The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both the rewarding and locomotor stimulating effects of cocaine in a place conditioning task, including several strains or substrains that have not yet been characterized for some or all of these behaviors.
Methods
C57BL/6J (B6), BALB/cJ (BALB), C3H/HeJ (C3H), DBA/2J (D2), FVB/NJ (FVB) and 129S1/SvImJ (129) mice were tested for conditioned place preference to 20 mg/kg cocaine.
Results
Place preference was observed in most strains with the exception of D2 and 129. All strains showed a marked increase in locomotor activity in response to cocaine. In BALB mice, however, locomotor activation was context-dependent. Locomotor sensitization to repeated exposure to cocaine was most significant in 129 and D2 mice but was absent in FVB mice.
Conclusions
Genetic correlations suggest that no significant correlation between conditioned place preference, acute locomotor activation, and locomotor sensitization exists among these strains indicating that separate mechanisms underlie the psychomotor and rewarding effects of cocaine.
Publisher
Springer Science and Business Media LLC
Subject
Behavioral Neuroscience,Biological Psychiatry,Cognitive Neuroscience,General Medicine
Reference52 articles.
1. Uhl GR, Elmer GI, LaBuda MC, Pickens RW: Genetic Influences in Drug Abuse. Psychopharmacology: The fourth generation of progress. Edited by: Bloom FE, Kupfer DJ. 1995, New York: Raven Press, 1793-1806.
2. Crabbe JC, Belknap JK, Buck KJ: Genetic animal models of alcohol and drug abuse. Science. 1994, 264: 1715-1723. 10.1126/science.8209252.
3. George FR, Goldberg SR: Genetic approaches to the analysis of addiction processes. Trends Pharmacol Sci. 1989, 10: 78-83. 10.1016/0165-6147(89)90083-7.
4. Seale TW, Carney JM: Genetic determinants of susceptibility to the rewarding and other behavioral actions of cocaine. J Addict Dis. 1991, 10: 141-162. 10.1300/J069v10n01_10.
5. Cunningham CL, Gremel CM, Groblewski PA: Drug-induced conditioned place preference and aversion in mice. Nat Protoc. 2006, 1: 1662-1670. 10.1038/nprot.2006.279.
Cited by
50 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献