Author:
Datta Susmita R,McQuillin Andrew,Puri Vinay,Choudhury Khalid,Thirumalai Srinivasa,Lawrence Jacob,Pimm Jonathan,Bass Nicholas,Lamb Graham,Moorey Helen,Morgan Jenny,Punukollu Bhaskar,Kandasami Gomathinayagam,Kirwin Simon,Sule Akeem,Quested Digby,Curtis David,Gurling Hugh MD
Abstract
Abstract
Background
Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia.
Methods
We used the case control design to test for of allelic and haplotypic association with schizophrenia in a sample of four hundred and fifty research subjects with schizophrenia and four hundred and fifty ancestrally matched supernormal controls. We genotyped the SNP markers previously found to be significantly associated with schizophrenia in the original study and also other markers found to be positive in subsequent studies.
Results
We could find no evidence of allelic, genotypic or haplotypic association with schizophrenia in our UK sample.
Conclusion
The results suggest that the DTNBP1 gene contribution to schizophrenia must be rare or absent in our sample. The discrepant allelic association results in previous studies of association between DTNBP1 and schizophrenia could be due population admixture. However, even positive studies of European populations do not show any consistent DTNBP1 alleles or haplotypes associated with schizophrenia. Further research is needed to resolve these issues. The possible confounding of linkage with association in family samples already showing linkage at 6p22.3 might be revealed by testing genes closely linked to DTNBP1 for allelic association and by restricting family based tests of association to only one case per family.
Publisher
Springer Science and Business Media LLC
Subject
Behavioral Neuroscience,Biological Psychiatry,Cognitive Neuroscience,General Medicine
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