Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia
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Published:2009-07-08
Issue:1
Volume:5
Page:
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ISSN:1744-9081
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Container-title:Behavioral and Brain Functions
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language:en
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Short-container-title:Behav Brain Funct
Author:
Bass Nicholas J,Datta Susmita R,McQuillin Andrew,Puri Vinay,Choudhury Khalid,Thirumalai Srinivasa,Lawrence Jacob,Quested Digby,Pimm Jonathan,Curtis David,Gurling Hugh MD
Abstract
Abstract
Background
Previous linkage and association studies have implicated the D-amino acid oxidase activator gene (DAOA)/G30 locus or neighbouring region of chromosome 13q33.2 in the genetic susceptibility to both schizophrenia and bipolar disorder. Four single nucleotide polymorphisms (SNPs) within the D-amino acid oxidase (DAO) gene located at 12q24.11 have also been found to show allelic association with schizophrenia.
Methods
We used the case control method to test for genetic association with variants at these loci in a sample of 431 patients with schizophrenia, 303 patients with bipolar disorder and 442 ancestrally matched supernormal controls all selected from the UK population.
Results
Ten SNPs spanning the DAOA locus were genotyped in these samples. In addition three SNPs were genotyped at the DAO locus in the schizophrenia sample. Allelic association was detected between the marker rs3918342 (M23), 3' to the DAOA gene and both schizophrenia (χ2 = 5.824 p = 0.016) and bipolar disorder (χ2 = 4.293 p = 0.038). A trend towards association with schizophrenia was observed for two other DAOA markers rs3916967 (M14, χ2 = 3.675 p = 0.055) and rs1421292 (M24; χ2 = 3.499 p = 0.062). A test of association between a three marker haplotype comprising of the SNPs rs778293 (M22), rs3918342 (M23) and rs1421292 (M24) and schizophrenia gave a global empirical significance of p = 0.015. No evidence was found to confirm the association of genetic markers at the DAO gene with schizophrenia.
Conclusion
Our results provide some support for a role for DAOA in susceptibility to schizophrenia and bipolar disorder.
Publisher
Springer Science and Business Media LLC
Subject
Behavioral Neuroscience,Biological Psychiatry,Cognitive Neuroscience,General Medicine
Reference51 articles.
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