Author:
Shoji Tadahiro,Takeshita Ryosuke,Saito Tatsunori,Aida Takeshi,Sasou Shunichi,Baba Tsukasa
Abstract
Abstract
Background
Primary ovarian signet-ring cell carcinoma is extremely rare, with only five recent case reports. Almost all reported cases of ovarian signet-ring cell carcinoma have been treated with TC therapy and none have reported regarding the use of S-1/CDDP therapy. We report a case of primary ovarian signet-ring cell carcinoma treated postoperatively with S-1/CDDP therapy.
Case presentation
We describe a 55-year-old woman diagnosed with stage IB primary ovarian signet-ring cell carcinoma that was treated with S-1/CDDP therapy. Preoperative transvaginal ultrasonography and contrast-enhanced computed tomography (CT) revealed a solid tumor measuring 10 cm in diameter in the pelvis. The tumor marker levels were as follows: CA125, 41.6 U/mL; CA19–9, < 2.0 U/mL; and CEA, 2.2 ng/mL. Ovarian cancer was suspected, and total abdominal hysterectomy, bilateral salpingo-oophorectomy, and omentectomy were performed. The left ovary was enlarged to greater than fist-sized, and there was a small amount of clear yellow ascites. Histological examination of the left ovary led to the diagnosis of signet-ring cell carcinoma. Histological examination of the right ovary also showed the presence of a signet-ring cell carcinoma. After surgery, upper and lower gastrointestinal endoscopy and positron-emission tomography-CT were performed to search for a possible primary lesion, but none was found. The patient was diagnosed with primary ovarian signet-ring cell carcinoma with FIGO Stage IB (PT1b, NX, M0). As postoperative adjuvant chemotherapy, S-1/CDDP therapy (S-1120 mg/day/body × 14 days, CDDP 50 mg/m2 day 8, q 21 days) was administered for six cycles. There was no recurrence 27 months after the initial treatment.
Conclusions
We considered S-1/CDDP therapy was effective for primary ovarian signet-ring cell carcinoma. This is the first case report of primary ovarian signet-ring cell carcinoma treated with S-1/CDDP therapy in the world.
Publisher
Springer Science and Business Media LLC
Subject
Obstetrics and Gynecology,Oncology
Reference17 articles.
1. Berek JS, Natarajan S. Ovarian and fallopian tube cancer. In: Rerek JS, editor. Berek and Novak's Gynecology. 14th ed. Philadelphia: Lippincott Williams and Wilkins; 2007. p. 1457e1554.
2. Su RM, Chang KC, Chou CY. Signet-ring stromal tumor of the ovary: a case report. Int J Gynecol Cancer. 2003;13:90–3.
3. El-Safadi S, Stahl U, Tinneberg HR, Hackethal A, Muenstedt K. Primary signet ring cell mucinous ovarian carcinoma: a case report and literature review. Case Rep Oncol. 2010;3:451–7.
4. Ogawa S, Inoue S, Ogiwara S, Kitamura C, Kawarabayashi Y, Ichinoe A, et al. A case of primary signet ring cell carcinoma of the ovary. The J Fukuoka College Obstet Gynecol. 2012;36:13–6.
5. Jaya Ganesh P, Vimal Chander R, Kachana MP, Narasimhan L. Primary ovarian mucinous carcinoma with signet ring cells - report of a rare case. J Clin Diagn Res. 2014;8:FD12–3..
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献