Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture

Author:

Coletta Ciro,Módis Katalin,Oláh Gábor,Brunyánszki Attila,Herzig Daniela S,Sherwood Edward R,Ungvári Zoltán,Szabo Csaba

Publisher

Springer Science and Business Media LLC

Subject

Critical Care and Intensive Care Medicine

Reference69 articles.

1. Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2001, 348: 1546-1554. 10.1056/NEJMoa022139.

2. Martin GS, Mannino DM, Moss M: The effect of age on the development and outcome of adult sepsis. Crit Care Med. 2006, 34: 15-21. 10.1097/01.CCM.0000194535.82812.BA.

3. Altura BM, Gebrewold A, Burton RW: Failure of microscopic metarterioles to elicit vasodilator responses to acetylcholine, bradykinin, histamine and substance P after ischemic shock, endotoxemia and trauma: possible role of endothelial cells. Microcirc Endothelium Lymphatics. 1985, 2: 121-127.

4. Szabo C, Farago M, Horvath I, Lohinai Z, Kovach AG: Hemorrhagic hypotension impairs endothelium-dependent relaxations in the renal artery of the cat. Circ Shock. 1992, 36: 238-241.

5. Wang P, Ba ZF, Chaudry IH: Endothelial cell dysfunction occurs after hemorrhage in nonheparinized but not in preheparinized models. J Surg Res. 1993, 54: 499-506. 10.1006/jsre.1993.1077.

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