The impact of COVID-19 critical illness on new disability, functional outcomes and return to work at 6 months: a prospective cohort study

Author:

Hodgson Carol L.ORCID,Higgins Alisa M.,Bailey Michael J.,Mather Anne M.,Beach Lisa,Bellomo RinaldoORCID,Bissett Bernie,Boden Ianthe J.,Bradley Scott,Burrell Aidan,Cooper D. JamesORCID,Fulcher Bentley J.,Haines Kimberley J.,Hopkins Jack,Jones Alice Y. M.,Lane Stuart,Lawrence Drew,van der Lee Lisa,Liacos Jennifer,Linke Natalie J.,Gomes Lonni Marques,Nickels Marc,Ntoumenopoulos George,Myles Paul S.,Patman Shane,Paton Michelle,Pound Gemma,Rai Sumeet,Rix Alana,Rollinson Thomas C.,Sivasuthan Janani,Tipping Claire J.,Thomas Peter,Trapani Tony,Udy Andrew A.,Whitehead Christina,Hodgson Isabelle T.,Anderson Shannah,Neto Ary Serpa,Burgess Nicola,Hearn Kirsty,Brewster David,Waanders Alyssa,Simpson Shannon,de Silva Yasmin,Lang Jenna,Burleigh Sarah,Killer Elisha,Wang Michael,O’Connor Lauren,Thomas Lauren,Dennis Lucy,Caruana Joanna,Al-Bassam Wisam,Shealy Morag,Chapman Marianne,O’Connor Stephanie,Sheehan Janne,Alexander Emily,Sukkar Amanda,Davis Liesl,Bass Francis,Hammond Naomi,O’Connor Anne,Yarad Elizabeth,Buhr Richard Totaro Heidi,Reddy Nazmeen,Chaseling Wendy,Ip Kelvin,Tronstad Oystein,Mahoney Alison,Fanning Cadi,Esterman Hariette,Kozary Alexia,Scott Bronte,Urquhart Donna,

Abstract

Abstract Background There are few reports of new functional impairment following critical illness from COVID-19. We aimed to describe the incidence of death or new disability, functional impairment and changes in health-related quality of life of patients after COVID-19 critical illness at 6 months. Methods In a nationally representative, multicenter, prospective cohort study of COVID-19 critical illness, we determined the prevalence of death or new disability at 6 months, the primary outcome. We measured mortality, new disability and return to work with changes in the World Health Organization Disability Assessment Schedule 2.0 12L (WHODAS) and health status with the EQ5D-5LTM. Results Of 274 eligible patients, 212 were enrolled from 30 hospitals. The median age was 61 (51–70) years, and 124 (58.5%) patients were male. At 6 months, 43/160 (26.9%) patients died and 42/108 (38.9%) responding survivors reported new disability. Compared to pre-illness, the WHODAS percentage score worsened (mean difference (MD), 10.40% [95% CI 7.06–13.77]; p < 0.001). Thirteen (11.4%) survivors had not returned to work due to poor health. There was a decrease in the EQ-5D-5LTM utility score (MD, − 0.19 [− 0.28 to − 0.10]; p < 0.001). At 6 months, 82 of 115 (71.3%) patients reported persistent symptoms. The independent predictors of death or new disability were higher severity of illness and increased frailty. Conclusions At six months after COVID-19 critical illness, death and new disability was substantial. Over a third of survivors had new disability, which was widespread across all areas of functioning. Clinical trial registrationNCT04401254 May 26, 2020.

Funder

National Health and Medical Research Council

Publisher

Springer Science and Business Media LLC

Subject

Critical Care and Intensive Care Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3