Rapamycin up-regulates triglycerides in hepatocytes by down-regulating Prox1-Reference-Cited by-同舟云学术

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Rapamycin up-regulates triglycerides in hepatocytes by down-regulating Prox1

Published:2016-02-27 Issue:1 Volume:15 Page:
ISSN:1476-511X
Container-title:Lipids in Health and Disease
language:en
Short-container-title:Lipids Health Dis

Author:

Kwon Sora,Jeon Ji-Sook,Kim Su Bin,Hong Young-Kwon,Ahn Curie,Sung Jung-Suk,Choi Inho

Funder

Academic Research fund of Hoseo University in 2012

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Endocrinology, Diabetes and Metabolism

Link

http://link.springer.com/content/pdf/10.1186/s12944-016-0211-x

Reference31 articles.

1. Wigle JT, Oliver G. Prox1 function is required for the development of the murine lymphatic system. Cell. 1999;98:769–78.

2. Dudas J, Elmaouhoub A, Mansuroglu T, Batusic D, Tron K, Saile B, et al. Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from “oval cells”. Histochem Cell Biol. 2006;126:549–62.

3. Lee S, Choi I, Hong Y-K. Heterogeneity and plasticity of lymphatic endothelial cells. Semin Thromb Hemost. 2010;36:352–62.

4. Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K, et al. Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet. 2005;37:1072–81.

5. Qin J, Gao DM, Jiang QF, Zhou Q, Kong YY, Wang Y, et al. Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene. Mol Endocrinol. 2004;18:2424–39.

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1. Knockdown of PROX1 promotes milk fatty acid synthesis by targeting PPARGC1A in dairy goat mammary gland;International Journal of Biological Macromolecules;2024-05

2. Case report: Severe asymptomatic hypertriglyceridemia associated with long-term low-dose rapamycin administration in a healthy middle-aged Labrador retriever;Frontiers in Veterinary Science;2023-11-29

3. A mixed blessing for liver transplantation patients — Rapamycin;Hepatobiliary & Pancreatic Diseases International;2023-02

4. Regulation of cellular LDL uptake by PROX1 and CHD7;2022-09-20

5. Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna;Science Advances;2022-09-16

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