Author:
Wang Lili,Liu Tao,Zhang Qingdui,Wang Lele,Zhou Qiang,Wang Jing,Miao Hao,Hao Ji,Qi Chunmei
Abstract
Abstract
Background and objective
Although the the Dietary Inflammatory Index (DII) serves to be one of the reliable indicator for hyperlipidaemia, there is still uncertainty about its relationship to prognosis in the hyperlipidaemic population. In current study, the DII levels were analyzed in relation to the mortality risk among among the hyperlipidaemic individuals with the aim of determining any prospective correlation.
Methods
14,460 subjects with hyperlipidaemia from the 10-year (2001–2010) National Health and Nutrition Examination Survey (NHANES) were chosen for this study. The endpoint event for follow-up was all-cause mortality, and subjects were tracked for up to December 31, 2019, or death, whichever occurred first. The tertiles of the DII levels were utilized for categorizing the study population into three groups. Survival curves, Cox proportional hazards regression models, restricted cubic spline (RCS), subgroup and interaction analyses, and sensitivity analyses were employed sequentially for the purpose of evaluating the association of the DII with mortality.
Results
3170 (21.92%) all-cause deaths were recorded during an average 148-month follow-up period. Kaplan-Meier survival curves indicated that the survival rate of participants divided into the low DII group was substantially improved compared to that of those in the higher DII group (log-rank P < 0.001). After controlling for confounders, higher levels of DII were observed to be meaningfully linked to an elevated risk of death, no matter whether DII was specified for the continuous (hazard ratio (HR): 1.06; 95% confidence interval (CI): 1.04–1.08) or the categorical variable (HR: 1.22; 95% CI: 1.11–1.33). The DII and mortality displayed a linear association, according to the RCS. Stratified and sensitivity analyses reinforced the proof that these findings were reliable.
Conclusion
Among patients with hyperlipidaemia, the risk of death was positively and linearly linked with DII levels.
Funder
The Shanghai Jinshan District Health Commission Project Fund
Shanghai University of Medical & Health Sciences Research Fund Project
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Endocrinology, Diabetes and Metabolism
Reference35 articles.
1. Alloubani A, Nimer R, Samara R. Relationship between Hyperlipidemia, Cardiovascular Disease and Stroke: a systematic review. Curr Cardiol Rev. 2021;17:e051121189015.
2. Lu Y, Li SX, Liu Y, Rodriguez F, Watson KE, Dreyer RP, Khera R, Murugiah K, D’Onofrio G, Spatz ES, et al. Sex-specific risk factors Associated with First Acute Myocardial Infarction in young adults. JAMA Netw Open. 2022;5:e229953.
3. Hill MF, Bordoni B, Hyperlipidemia. 2023. Treasure Island (FL).
4. Karr S. Epidemiology and management of hyperlipidemia. Am J Manag Care. 2017;23:139–S148.
5. Du H, Shi Q, Song P, Pan XF, Yang X, Chen L, He Y, Zong G, Zhu Y, Su B, Li S. Global Burden Attributable to High Low-Density lipoprotein-cholesterol from 1990 to 2019. Front Cardiovasc Med. 2022;9:903126.
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