Abstract
AbstractObesity and its complications constitute a substantial burden. Considerable published research describes the novel relationships between obesity and gut microbiota communities. It is becoming evident that microbiota behave in a pivotal role in their ability to influence homeostatic mechanisms either to the benefit or detriment of host health, the extent of which is not fully understood. A greater understanding of the contribution of gut microbiota towards host pathophysiology is revealing new therapeutic avenues to tackle the global obesity epidemic. This review focuses on causal relationships and associations with obesity, proposed central mechanisms encouraging the development of obesity and promising prospective methods for microbiota manipulation.
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry, medical,Clinical Biochemistry,Endocrinology,Endocrinology, Diabetes and Metabolism
Reference130 articles.
1. : World Health Organisation. Obesity and overweight. 2020. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accessed 17 March 2021.
2. Power ML, Schulkin J. The evolution of obesity. Baltimore: The Johns Hopkins University Press; 2009.
3. World Health Organisation. Obesity. https://www.who.int/health-topics/obesity#tab=tab_1. Accessed 17 Mar 2021.
4. : Komaroff AL. The microbiome and risk for obesity and diabetes. JAMA. 2017;317(4):355–356, DOI: https://doi.org/10.1001/jama.2016.20099.
5. Canfora EE, Jocken JW, Blaak EE. Short-chain fatty acids in control of body weight and insulin sensitivity. Nat Rev Endocrinol. 2015;11(10):577–91. https://doi.org/10.1038/nrendo.2015.128.
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