Author:
Chen Xinyue,Song Chenxin,Ma Xianrun,Tao Junjie,Hu Lijuan,Xu Yuan,Yi Yingping,Yang Xinlei,Jiang Long
Abstract
Abstract
Background
Moyamoya disease (MMD) has attracted the attention of scholars because of its rarity and unknown etiology.
Methods
Data for this study were sourced from the Second Affiliated Hospital of Nanchang University. Regression analyses were conducted to examine the association in Lipoprotein [Lp(a)] and MMD. R and IBM SPSS were conducted.
Results
A cohort comprising 1012 MMD patients and 2024 controls was established through the propensity score matching method. Compared with controls, MMD patients showed higher median Lp(a) concentrations [18.5 (9.6–37.8) mg/dL vs. 14.9 (7.8–30.5) mg/dL, P < 0.001]. The odds ratios and 95% confidence intervals for Lp(a) were calculated in three models: unadjusted model, model 1 (adjusted for body mass index and systolic blood pressure), and model 2 (adjusted for model 1 plus triglyceride, C-reactive protein, homocysteine, and low-density lipoprotein cholesterol). Results were [1.613 (1.299–2.002), P < 0.001], [1.598 (1.286–1.986), P < 0.001], and [1.661 (1.330–2.074), P < 0.001], respectively. Furthermore, age, sex, or hypertension status had nothing to do with this relationship.
Conclusions
Positive relationship exists between Lp(a) and MMD.
Funder
Key R&D Program (general projects) of Jiangxi Provincial Department of Science and Technology
Applied research and cultivation program of Jiangxi Provincial Department of Science and Technology
National Key R&D Program of China
National Natural Science Foundation for Young Scientists of China
Natural Science Foundation of Jiangxi Province for Distinguished Young Scholars of China
Natural Science Foundation of Jiangxi Province for Young Scientists of China
Nanchang University Youth Teacher Training Fund
Project of Jiangxi Provincial Health and Family Planning Commission
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Endocrinology, Diabetes and Metabolism