Author:
Shi Qingmiao,Chu Qingfei,Zeng Yifan,Yuan Xin,Wang Jinzhi,Zhang Yaqi,Xue Chen,Li Lanjuan
Abstract
AbstractRNA methylation modification plays a crucial role as an epigenetic regulator in the oncogenesis of hepatocellular carcinoma (HCC). Numerous studies have investigated the molecular mechanisms underlying the methylation of protein-coding RNAs in the progression of HCC. Beyond their impact on mRNA, methylation modifications also influence the biological functions of non-coding RNAs (ncRNAs). Here, we present an advanced and comprehensive overview of the interplay between methylation modifications and ncRNAs in HCC, with a specific focus on their potential implications for the tumor immune microenvironment. Moreover, we summarize promising therapeutic targets for HCC based on methylation-related proteins. In the future, a more profound investigation is warranted to elucidate the effects of ncRNA methylation modifications on HCC pathogenesis and devise valuable intervention strategies.
Funder
Fundamental Research Funds for the Central Universities
the Shandong Provincial Laboratory Project
the Research Project of Jinan Micro-ecological Biomedicine Shandong Laboratory
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry