PKCδ regulates the vascular biology in diabetic atherosclerosis-Reference-Cited by-同舟云学术

PKCδ regulates the vascular biology in diabetic atherosclerosis

Published:2023-11-16 Issue:1 Volume:21 Page:
ISSN:1478-811X
Container-title:Cell Communication and Signaling
language:en
Short-container-title:Cell Commun Signal

Author:

Qin Peiliang,He Changhuai,Ye Pin,Li Qin,Cai Chuanqi,Li Yiqing

Abstract

AbstractDiabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)–protein kinase C (PKC) pathway plays an important role in atherosclerosis. PKCs can be divided into three subgroups: conventional PKCs (cPKCs), novel PKCs (nPKCs), and atypical PKCs (aPKCs). The aim of this review is to provide a comprehensive overview of the role of the PKCδ pathway, an isoform of nPKC, in regulating the function of endothelial cells, vascular smooth muscle cells, and macrophages in diabetic atherosclerosis. In addition, potential therapeutic targets regarding the PKCδ pathway are summarized.

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://link.springer.com/content/pdf/10.1186/s12964-023-01361-4.pdf

Reference146 articles.

1. Sun H, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183: 109119.

2. Geraldes P, King GL. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res. 2010;106(8):1319–31.

3. Low Wang CC, Hess CN, Hiatt WR, Goldfine AB. Clinical update: Cardiovascular disease in diabetes mellitus. Circulation. 2016;133(24):2459–502.

4. Kikkawa U, Matsuzaki H, Yamamoto T. Protein kinase Cδ(PKC δ): activation mechanisms and functions. J Biochem. 2002;132(6):831–9.

5. Miao LN, et al. Role and mechanism of PKC-δ for cardiovascular disease: current status and perspective. Front Cardiovasc Med. 2022;9(February):1–16.

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Integrative analysis of single-Cell RNA sequencing and experimental validation in the study of abdominal aortic aneurysm progression;Gene;2024-12

2. Evaluating the impact of type 2 diabetes mellitus on pulmonary vascular function and the development of pulmonary fibrosis;Frontiers in Endocrinology;2024-07-10

3. Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial apoptosis in diabetic wound healing;Cell Death Discovery;2024-05-29