Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation-Reference-Cited by-同舟云学术

Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation

Published:2019-06-06 Issue:1 Volume:17 Page:
ISSN:1478-811X
Container-title:Cell Communication and Signaling
language:en
Short-container-title:Cell Commun Signal

Author:

Lauter Markus,Weber Anja,Torka Robert^ORCID

Funder

HaPKom

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

http://link.springer.com/content/pdf/10.1186/s12964-019-0377-8.pdf

Reference44 articles.

1. Myers SH, Brunton VG, Unciti-Broceta A. AXL inhibitors in Cancer: a medicinal chemistry perspective. J Med Chem. 2016;59:3593–608.

2. Graham DK, DeRyckere D, Davies KD, Earp HS. The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer. Nat Rev Cancer. 2014;14:769–85.

3. Vouri M, Hafizi S. TAM receptor tyrosine kinases in Cancer drug resistance. Cancer Res. 2017;77:2775–8.

4. Gay CM, Balaji K, Byers LA. Giving AXL the axe: targeting AXL in human malignancy. Br J Cancer. 2017;116:415–23.

5. Mudduluru G, Leupold JH, Stroebel P, Allgayer H. PMA up-regulates the transcription of Axl by AP-1 transcription factor binding to TRE sequences via the MAPK cascade in leukaemia cells. Biol Cell. 2010;103:21–33.

Cited by 20 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent discovery and development of AXL inhibitors as antitumor agents;European Journal of Medicinal Chemistry;2024-06

2. Ningetinib plus gefitinib in EGFR-mutant non-small-cell lung cancer with MET and AXL dysregulations: A phase 1b clinical trial and biomarker analysis;Lung Cancer;2024-02

3. Discovery of novel and potent dual-targeting AXL/HDAC2 inhibitors for colorectal cancer treatment via structure-based pharmacophore modelling, virtual screening, and molecular docking, molecular dynamics simulation studies, and biological evaluation;Journal of Enzyme Inhibition and Medicinal Chemistry;2023-12-22

4. The Tolerogenic Influence of Dexamethasone on Dendritic Cells Is Accompanied by the Induction of Efferocytosis, Promoted by MERTK;International Journal of Molecular Sciences;2023-11-02

5. Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders;Frontiers in Immunology;2023-07-20