Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction
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Published:2023-10-30
Issue:1
Volume:21
Page:
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ISSN:1478-811X
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Container-title:Cell Communication and Signaling
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language:en
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Short-container-title:Cell Commun Signal
Author:
Xue Chongxiang,Chen Keyu,Gao Zezheng,Bao Tingting,Dong LiShuo,Zhao Linhua,Tong Xiaolin,Li Xiuyang
Abstract
AbstractDiabetic vascular complications (DVCs), including macro- and micro- angiopathy, account for a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial dysfunction is the initial and role step for the pathogenesis of DVCs. Hyperglycemia and lipid metabolism disorders contribute to endothelial dysfunction via direct injury of metabolism products, crosstalk between immunity and inflammation, as well as related interaction network. Although physiological and phenotypic differences support their specified changes in different targeted organs, there are still several common mechanisms underlying DVCs. Also, inhibitors of these common mechanisms may decrease the incidence of DVCs effectively. Thus, this review may provide new insights into the possible measures for the secondary prevention of DM. And we discussed the current limitations of those present preventive measures in DVCs research.
Funder
Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine
Scientific and Technological innovation project of China Academy of Chinese Medical Sciences
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry
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