Author:
Yang Yan,Zhu Guangming,Yang Li,Yang Yun
Abstract
AbstractCluster of differentiation 24 (CD24), a mucin-like highly glycosylated molecule has been extensively studied as a cancer stem cell marker in a variety of solid cancers. The functional role of CD24 is either fulfilled by combining with ligands or participating in signal transduction, which mediate the initiation and progression of neoplasms. Recently, CD24 was also described as an innate immune checkpoint with apparent significance in several types of solid cancers. Herein, we review the current understanding of the molecular fundamentals of CD24, the role of CD24 in tumorigenesis and cancer progression, the possibility as a promising therapeutic target and summarized different therapeutic agents or strategies targeting CD24 in solid cancers.
Funder
Natural Science Foundation of Henan
Key Scientific Research Project of Higher Education of Henan Province
Science & Technology Innovation Talents in Universities of Henan Province
Training Plan for Young Backbone Teachers in Universities of Henan Province
Science & Technology Project for Young Talents of Henan Province
Key Science & Technology Project of Xinxiang
Open Program of International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan
National College Students' Innovation and Entrepreneurship Training Program
Innovation project of Graduate in Xinxiang Medical University
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
11 articles.
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