Author:
Du Juan,Huang Tianyi,Zheng Zhen,Fang Shuai,Deng Hongxia,Liu Kaitai
Abstract
AbstracttsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, as well as involvement in cellular differentiation, proliferation, and apoptosis. tsRNA-related abnormalities have a significant influence on the onset, development, and progression of numerous human diseases, including malignant tumors through affecting the cell cycle and specific signaling molecules. This review introduced origins together with tsRNAs classification, providing a summary for regulatory mechanism and physiological function while dysfunctional effect of tsRNAs in digestive system diseases, focusing on the clinical prospects of tsRNAs for diagnostic and prognostic biomarkers.
Funder
NINGBO Leading Medical & Health Discipline
the Ningbo Natural Science Foundation
the Medical Science and Technology Project of Zhejiang Provincial Health Commission
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
3 articles.
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