Abstract
Abstract
Background
Damage to the inner ear or cochlear nerve results in sensorineural hearing loss (SNHL), which is typically persistent deafness. SNHL can range in severity from mild to profound. The shape of the audiogram is used to categorise it as high-frequency hearing loss, low-frequency, flat, peaked, or notched. Pure tone audiometry can be used to diagnose SNHL.
Objective
To summarise the recent updates in the usage of stem cells in sensory neural hearing loss (SNHL).
Methods
Published studies about using stem cell therapy in ENT practice through comprehensive PubMed, EKG, and Google Scholar search (from 2010 to 2022). Including studies in English, experimental studies, and studies that discuss the application of regenerative medicine in SNHL.
Results
Progenitor stem cells may be employed to repair damaged cells and restore sensorineural hearing function, according to 36 of the publications. The majority of these articles—about 90%—discussed animal model-based experimental investigations; the remaining 10% were clinical trials.
Conclusion
The application of stem cells in the treatment of SNHL will be a significant step in the future since it will change the way that patients are now treated in the hopes of regaining their hearing. The application to the clinical setting is still in its early stage, although a number of encouraging researches illustrate how progenitor stem cells differentiate into sensorineural cells.
Publisher
Springer Science and Business Media LLC
Reference47 articles.
1. Lin FR, Niparko JK, Ferrucci L (2011) Hearing loss prevalence in the United States. Arch Intern Med 171(20):1851–1852
2. Mehra S, Eavey RD, Keamy DG (2009) The epidemiology of hearing impairment in the United States: newborns, children, and adolescents. Otolaryngol Head Neck Surg 4(140):461–472
3. Sheearer AE, Shibata SB, Smith RJH (2020) Genetic sensorinerual hearing loss. In: Flint PW, Haughey BH, Lund VJ, Niparko JK, Robbins KT, Thomas JR, et al, editors. Cummings Otolaryngology—Head and Neck Surgery, 7th edn. Saunders, an imprint of Elsevier, Philladepphia, p 2279-2292
4. Orlando G, Baptista P, Birchall M, De Coppi P, Farney A, Guimaraes-Souza NK, ..., Soker S (2011) Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transpl Int 24(3):223–232
5. Cox CS, Baumgartner JE, Jimenez F, Gee A, Harting MT (2011) Autologous Bone Marrow Mononuclear Cell Therapy for Severe Traumatic Brain Injury in Children. Neurosurgery 68(3):588–600