Author:
Bliźniewska-Kowalska Katarzyna,Gałecki Piotr,Szemraj Janusz,Su Kuan-Pin,Chang Jane Pei-Chen,Gałecka Małgorzata
Abstract
Abstract
Background
The aim of our study was to evaluate the expression of the CASP3 gene at both mRNA and protein levels in patients with depressive disorders and to determine the impact of caspase 3 in the pathogenesis of depression;
Methods
A total of 290 subjects, including 190 depressed patients and 100 healthy controls, participated in the study. Socio-demographic and clinical data were collected, and the severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale. Venous blood was collected and gene expression was evaluated using RT-PCR and ELISA at the mRNA and protein levels, respectively;
Results
The expression of the CASP3 gene was significantly lower in depressed patients compared to healthy controls at both the mRNA and protein levels. Additionally, a positive correlation was observed between CASP3 gene expression and disease duration as well as the number of depressive episodes;
Conclusions
Further studies are needed to investigate the role of caspase 3 in depressive disorders.
Funder
Uniwersytet Medyczny w Lodzi
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health
Reference37 articles.
1. World Health Organization. available online: https://www.who.int/news-room/fact-sheets/detail/depression (Accessed July 1st, 2023).
2. D’Amelio M, Cavallucci V, Cecconi F. Neuronal caspase-3 signaling: not only cell death. Cell Death Differ. 2010;17:1104–14. https://doi.org/10.1038/cdd.2009.180.
3. Tzeng TT, Tsay HJ, Chang L, et al. Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid. J Biomed Sci. 2013;20:90. https://doi.org/10.1186/1423-0127-20-90.
4. Avdeev DB, Stepanov SS, Gorbunova AV, et al. Immunohistochemical signs of apoptosis and neuroplasticity in the cerebral cortex of white rats after occlusion of the common carotid arteries. Neurosci Behav Physi. 2020;50:804–9. https://doi.org/10.1007/s11055-020-00969-0.
5. The ICD-10. Classification of Mental and behavioural Disorders: Diagnostic Criteria for Research. World Health Organization; 1993.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献