ARFID Genes and Environment (ARFID-GEN): study protocol

Author:

Bulik Cynthia M.,Micali Nadia,MacDermod Casey M.,Qi Baiyu,Munn-Chernoff Melissa A.,Thornton Laura M.,White Jennifer,Dinkler Lisa,Pisetsky Emily M.,Johnson Jessica,Devine Katelin R.,Ortiz Shelby N.,Silverman Ava E.,Berthold Natasha,Dumain Alexis,Guintivano Jerry,Halvorsen Matthew,Crowley James J.

Abstract

Abstract Background The Avoidant Restrictive Food Intake Disorder – Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults. Methods A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18 +) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted. Discussion ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver “actionable” findings that can be transformed into clinically meaningful insights. Trial registration ARFID-GEN is a registered clinical trial: clinicaltrials.gov NCT05605067.

Funder

National Institute of Mental Health

Karolinska Institute

Publisher

Springer Science and Business Media LLC

Subject

Psychiatry and Mental health

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