Treatment with aripiprazole once-monthly injectable formulation is effective in improving symptoms and global functioning in schizophrenia with and without comorbid substance use – a post hoc analysis of the ReLiAM study

Author:

Margolese Howard C.ORCID,Boucher Matthieu,Therrien Francois,Clerzius Guerline

Abstract

Abstract Background ReLiAM, Real-Life Assessment of Abilify Maintena, was the first reported long-term prospective non-interventional study for patients with schizophrenia treated with aripiprazole once-monthly injectable formulation (AOM) under real-life conditions. ReLiAM’s primary aim was to evaluate the evolution of global functional status in patients treated with AOM for 12 months in Canada. Methods The objective of this post hoc analysis of the ReLiAM study is to investigate the treatment effects of real-life use of AOM over a 1-year period in the subgroup of patients with reported substance use compared with patients without substance use. Results The results of this post hoc analysis demonstrate that treatment with AOM for 12 months in patients with schizophrenia was comparably effective in improving global functioning in subgroups of patients with and without concomitant substance use. Conclusions These results support the use of AOM for the treatment of schizophrenia in patients with or without concomitant substance use. Trial registration ClinicalTrials.gov NCT02131415, first posted on May 6, 2014. Overall trial status: Terminated.

Funder

Lundbeck Canada Inc.

Otsuka Canada Pharmaceutical Inc.

Publisher

Springer Science and Business Media LLC

Subject

Psychiatry and Mental health

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