Author:
Yin Jiahui,Li Siyuan,Li Jinling,Gong Rongpeng,Jia Zhixia,Liu Junjun,Jin Zhi,Yang Jiguo,Liu Yuanxiang
Abstract
AbstractBackgroundAs the most abundant fatty acid in plasma, oleic acid has been found to be associated with multiple neurological diseases; however, results from studies of the relationship between oleic acid and depression are inconsistent.MethodsThis cross-sectional study analyzed 4,459 adults from the National Health and Nutrition Examination Survey 2011–2014. The following covariates were adjusted in multivariable logistic regression models: age, sex, race/ethnicity, education level, marital status, body mass index, physical activity, smoking status, alcohol status, metabolic syndrome, omega-3 polyunsaturated fatty acids, and total cholesterol.ResultsSerum oleic acid levels were positively associated with depression. After adjusting for all covariates, for every 1 mmol/L increase in oleic acid levels, the prevalence of depression increased by 40% (unadjusted OR: 1.35, 95%CI: 1.16–1.57; adjusted OR: 1.40, 95% CI: 1.03–1.90).ConclusionsOur study suggests that oleic acid may play a role in depression. Further research is needed to investigate the potential benefits of changing oleic acid levels for the treatment and prevention of depression.
Funder
Shandong Administration of Traditional Chinese Medicine
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health