QSAR studies on PIM1 and PIM2 inhibitors using statistical methods: a rustic strategy to screen for 5-(1H-indol-5-yl)-1,3,4-thiadiazol analogues and predict their PIM inhibitory activity-Reference-Cited by-同舟云学术

QSAR studies on PIM1 and PIM2 inhibitors using statistical methods: a rustic strategy to screen for 5-(1H-indol-5-yl)-1,3,4-thiadiazol analogues and predict their PIM inhibitory activity

Published:2017-05-19 Issue:1 Volume:11 Page:
ISSN:1752-153X
Container-title:Chemistry Central Journal
language:en
Short-container-title:Chemistry Central Journal

Author:

Aouidate Adnane,Ghaleb Adib,Ghamali Mounir,Chtita Samir,Choukrad M’barek,Sbai Abdelouahid,Bouachrine Mohammed,Lakhlifi Tahar

Funder

The Moroccan National Center of Technique and Scientific Research

Publisher

Springer Science and Business Media LLC

Subject

General Chemistry

Link

http://link.springer.com/content/pdf/10.1186/s13065-017-0269-1.pdf

Reference25 articles.

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2. Nawijn MC, Alendar A, Berns A (2011) For better or for worse: the role of Pim oncogenes in tumorigenesis. Nat Rev Cancer 11:23–34. doi: 10.1038/nrc2986

3. Qian K, Lian W, Cywin CL et al (2009) Hit to lead account of the discovery of a new class of inhibitors of pim kinases and crystallographic studies revealing an unusual kinase binding mode. J Med Chem 52:1814–1827. doi: 10.1021/jm801242y

4. Schulz MN, Fanghänel J, Schäfer M et al (2011) A crystallographic fragment screen identifies cinnamic acid derivatives as starting points for potent Pim-1 inhibitors. Acta Crystallogr Sect D Biol Crystallogr 67:156–166. doi: 10.1107/S0907444910054144

5. Gadewal N, Varma A (2012) Targeting Pim-1 kinase for potential drug-development. Int J Comput Biol Drug Des 5:137–151. doi: 10.1504/IJCBDD.2012.048303

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