Determination of flutamide and two major metabolites using HPLC–DAD and HPTLC methods

Author:

Abdelwahab Nada S.,Elshemy Heba A. H.,Farid Nehal F.

Publisher

Springer Science and Business Media LLC

Subject

General Chemistry

Reference30 articles.

1. Budavari S (2003) The merck index, 13th edn. Merck and Co Inc, Whitehouse Station

2. Sternal R, Nugara N (2001) Analytical Profiles of Drug Substances and Excipients, vol 27. Academic Press, California, p 116

3. Salgado HRN, Menezes M, Storti MPB (2005) Determination of flutamide in tablets by high-performance liquid chromatography. Acta Farmaceutica Bonaerense 24:246–249

4. Tevell A et al (2006) Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry. Drug Metabol Dispos 34:984–992

5. Goda R et al (2006) Detection of a new n-oxidized metabolite of flutamide, n-[4-nitro-3- (trifluoromethyl)phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients. Drug metabol. Dispos 34:828–835

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