Author:
Gill Muhammad Shoaib Ali,Azzman Nursyuhada,Hassan Sharifah Syed,Shah Syed Adnan Ali,Ahemad Nafees
Abstract
AbstractQuinolone is a privileged scaffold in medicinal chemistry and 4-Quinolone-3-Carboxamides have been reported to harbor vast therapeutic potential. However, conversion of N-1 substituted 4-Quinolone 3-Carboxylate to its corresponding carbamates is highly restrictive. This motivated us to adopt a much simpler, scalable and efficient methodology for the synthesis of highly pure N-1 substituted 4- Quinolone-3-Carboxamides with excellent yields. Our adopted methodology not only provides a robust pathway for the convenient synthesis of N-1 substituted 4- Quinolone-3-Carboxamides which can then be explored for their therapeutic potential, this may also be adaptable for the derivatization of other such less reactive carboxylate species.
Funder
Ministry of Higher Education, Malaysia
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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