G2D: a tool for mining genes associated with disease-Reference-Cited by-同舟云学术

G2D: a tool for mining genes associated with disease

Published:2005-08-22 Issue:1 Volume:6 Page:
ISSN:1471-2156
Container-title:BMC Genetics
language:en
Short-container-title:BMC Genet

Author:

Perez-Iratxeta Carolina,Wjst Matthias,Bork Peer,Andrade Miguel A

Abstract

Abstract Background Human inherited diseases can be associated by genetic linkage with one or more genomic regions. The availability of the complete sequence of the human genome allows examining those locations for an associated gene. We previously developed an algorithm to prioritize genes on a chromosomal region according to their possible relation to an inherited disease using a combination of data mining on biomedical databases and gene sequence analysis. Results We have implemented this method as a web application in our site G2D (Genes to Diseases). It allows users to inspect any region of the human genome to find candidate genes related to a genetic disease of their interest. In addition, the G2D server includes pre-computed analyses of candidate genes for 552 linked monogenic diseases without an associated gene, and the analysis of 18 asthma loci. Conclusion G2D can be publicly accessed at http://www.ogic.ca/projects/g2d_2/.

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics

Link

https://link.springer.com/content/pdf/10.1186/1471-2156-6-45.pdf

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