Author:
Payandeh Zahra,Pirpour Tazehkand Abbas,Azargoonjahromi Ali,Almasi Faezeh,Alagheband Bahrami Armina
Abstract
AbstractAuto-immune diseases involved at least 25% of the population in wealthy countries. Several factors including genetic, epigenetic, and environmental elements are implicated in development of Rheumatoid Arthritis as an autoimmune disease. Autoantibodies cause synovial inflammation and arthritis, if left untreated or being under continual external stimulation, could result in chronic inflammation, joint injury, and disability. T- and B-cells, signaling molecules, proinflammatory mediators, and synovium-specific targets are among the new therapeutic targets. Exosomes could be employed as therapeutic vectors in the treatment of autoimmune diseases. Herein, the role of cell organelle particularly exosomes in Rheumatoid Arthritis had discussed and some therapeutic applications of exosome highlighted.
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology
Reference123 articles.
1. Atassi M, Casali P. Analysis: autoimmune disorders: an overview of molecular and cellular basis in Today’s perspective. J Clin Cell Immunol. 2015;6:302.
2. Wang L, Wang FS, Gershwin ME. Human autoimmune diseases: a comprehensive update. J Intern Med. 2015;278(4):369–95.
3. Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology E-book: Elsevier health sciences; 2014.
4. Jancar S, Crespo MS. Immune complex-mediated tissue injury: a multistep paradigm. Trends Immunol. 2005;26(1):48–55.
5. Munoz LE, Lauber K, Schiller M, Manfredi AA, Herrmann M. The role of defective clearance of apoptotic cells in systemic autoimmunity. Nat Rev Rheumatol. 2010;6(5):280–9.
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