Author:
Liśkiewicz Arkadiusz,Przybyła Marta,Wojakowska Anna,Marczak Łukasz,Bogus Katarzyna,Nowacka-Chmielewska Marta,Liśkiewicz Daniela,Małecki Andrzej,Barski Jarosław,Lewin-Kowalik Joanna,Toborek Michal
Abstract
AbstractPhysical activity impacts brain functions, but the direct mechanisms of this effect are not fully recognized or understood. Among multidimensional changes induced by physical activity, brain fatty acids (FA) appear to play an important role; however, the knowledge in this area is particularly scarce. Here we performed global metabolomics profiling of the hippocampus and the frontal cortex (FC) in a model of voluntary running in mice. Examined brain structures responded differentially to physical activity. Specifically, the markers of the tricarboxylic acid (TCA) cycle were downregulated in the FC, whereas glycolysis was enhanced in the hippocampus. Physical activity stimulated production of myristic, palmitic and stearic FA; i.e., the primary end products of de novo lipogenesis in the brain, which was accompanied by increased expression of hippocampal fatty acid synthase (FASN), suggesting stimulation of lipid synthesis. The changes in the brain fatty acid profile were associated with reduced anxiety level in the running mice. Overall, the study examines exercise-related metabolic changes in the brain and links them to behavioral outcomes.
Funder
Narodowe Centrum Nauki
National Institute on Drug Abuse
National Institute of Mental Health
National Heart, Lung, and Blood Institute
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Molecular Biology
Cited by
14 articles.
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