Abstract
Abstract
Background
Abnormal white matter is a common neurobiological change in bipolar disorder, and dysregulation of myelination in oligodendrocytes (OLs) is the cause. Transmembrane protein 108 (Tmem108), as a susceptible gene of bipolar disorder, is expressed higher in OL lineage cells than any other lineage cells in the central nervous system. Moreover, Tmem108 mutant mice exhibit mania-like behaviors, belonging to one of the signs of bipolar disorder. However, it is unknown whether Tmem108 regulates the myelination of the OLs.
Results
Tmem108 expression in the corpus callosum decreased with the development, and OL progenitor cell proliferation and OL myelination were enhanced in the mutant mice. Moreover, the mutant mice exhibited mania-like behavior after acute restraint stress and were susceptible to drug-induced epilepsy.
Conclusions
Tmem108 inhibited OL progenitor cell proliferation and mitigated OL maturation in the corpus callosum, which may also provide a new role of Tmem108 involving bipolar disorder pathogenesis.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangxi Province
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Molecular Biology
Reference64 articles.
1. Mahon K, Burdickand KE, Szeszko PR. A role for white matter abnormalities in the pathophysiology of bipolar disorder. Neurosci Biobehav Rev. 2010;34(4):533–54.
2. Marlinge E, Bellivierand F, Houenou J. White matter alterations in bipolar disorder: potential for drug discovery and development. Bipolar Disord. 2014;16(2):97–112.
3. Hu R, Stavish C, Leibenluftand E, Linke JO. white matter microstructure in individuals with and at risk for bipolar disorder: evidence for an endophenotype from a voxel-based meta-analysis. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;5(12):1104–13.
4. Sehmbi M, Rowley CD, Minuzzi L, Kapczinski F, Kwiecien JM, Bock NA, et al. Age-related deficits in intracortical myelination in young adults with bipolar disorder type I. J Psychiatry Neurosci. 2019;44(2):79–88.
5. Linke JO, Adleman NE, Sarlls J, Ross A, Perlstein S, Frank HR, et al. White matter microstructure in pediatric bipolar disorder and disruptive mood dysregulation disorder. J Am Acad Child Adolesc Psychiatry. 2020;59(10):1135–45.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献