A natural marmoset model of genetic generalized epilepsy

Author:

Yang Xiangyu,Chen Zhitang,Wang Ziying,He Guang,Li Zhiqiang,Shi Yongyong,Gong Neng,Zhao Binglei,Kuang Yifang,Takahashi Eiki,Li WeidongORCID

Abstract

AbstractEpilepsy has been extensively studied as a common neurological disease. Efforts have been made on rodent and other animal models to reveal the pathogenic mechanisms of epilepsy and develop new drugs for treatment. However, the features of current epilepsy models cannot fully mimic different types of epilepsy in humans, hence non-human primate models of epilepsy are required. The common marmoset (Callithrix jacchus) is a New World monkey that is widely used to study brain function. Here, we present a natural marmoset model of generalized epilepsy. In this unique marmoset family, generalized epilepsy was successfully induced by handling operations in some individuals. We mapped the marmoset family with handling-sensitive epilepsy and found that the epileptic phenotype can be inherited. These marmosets were more sensitive to the epilepsy inducers pentylenetetrazol. Using electrocorticogram (ECoG) recordings, we detected epileptiform discharge in marmosets with a history of seizures. In summary, we report a family of marmosets with generalized seizures induced by handling operations. This epileptic marmoset family provides insights to better understand the mechanism of generalized epilepsy and helps to develop new therapeutic methods.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

the Open Topic Research Program of Shenzhen-Hong Kong Institute of Brain Science

Shanghai Municipal Commission of Science and Technology Program

Shanghai Municipal Science and Technology Major Project

Shanghai Education Commission Research and Innovation Program

Natural Science Foundation of Chongqing

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Molecular Biology

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