Abstract
AbstractBrown tumors or osteitis fibrosa cystica has become a rare presentation of primary hyperparathyroidism in up-to-date clinical practice. Here, we describe a case of longstanding untreated hyperparathyroidism presenting itself with brown tumors in a 65-year-old patient. During the diagnostic work-up of this patient, bone SPECT/CT and 18F-FDG-PET/CT revealed multiple widespread osteolytic lesions. Differentiating from other bone tumors such as multiple myeloma is challenging. In this case, the final diagnosis was made by integrating the medical history, biochemical diagnosis of primary hyperparathyroidism, pathological findings and medical imaging.
Publisher
Springer Science and Business Media LLC
Subject
Radiology, Nuclear Medicine and imaging,Molecular Medicine,Biophysics,Computer Science (miscellaneous)
Reference9 articles.
1. Bilezikian J, Brandi M, Rubin M, Silverberg S (2005) Primary hyperparathyroidism: new concepts in clinical, densitometric and biochemical features. J Intern Med 257(1):6–17
2. Chew FS, Huang-Hellinger F (1993) Brown tumor. Am J Roentgenol 160:752–752
3. Kalathas T, Kalatha T, Boultoukas E (2010) Brown tumors; a possible pitfall in diagnosing metastatic disease. Hell J Nucl Med 13(1):15–17
4. Liu J, Cusano N, Silva B, Zhao L, He X, Tao B et al (2013) Primary hyperparathyroidism: a tale of two cities revisited—New York and Shanghai. Bone Res 1(2):162–169
5. Misiorowski W, Czajka-Oraniec I, Kochman M, Zgliczyński W, Bilezikian J (2017) Osteitis fibrosa cystica—a forgotten radiological feature of primary hyperparathyroidism. Endocrine 58(2):380–385