Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT

Author:

Huber Sara,Lang Roland,Steiner Markus,Aglas Lorenz,Ferreira Fatima,Wallner Michael,Hawranek Thomas,Gadermaier GabrieleORCID

Funder

Österreichische Forschungsförderungsgesellschaft

Publisher

Wiley

Subject

Immunology and Allergy,Immunology,Pulmonary and Respiratory Medicine

Reference40 articles.

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2. EAACI White Paper on Research, Innovation and Quality Care. Zurich, Switzerland: European Academy of Allergy and Clinical Immunology; 2018. http://www.eaaci.org/documents/EAACI_White_Paper.pdf .

3. Burks AW, Calderon MA, Casale T, Cox L, Demoly P, Jutel M, Nelson H, Akdis CA. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. J Allergy Clin Immunol. 2013;131(1288–1296):e1283.

4. Plattsmills TAE, Maur RKV, Ishizaka K, Norman PS, Lichtenstein LM. Iga and Igg anti-ragweed antibodies in nasal secretions—quantitative measurements of antibodies and correlation with inhibition of histamine-release. J Clin Investig. 1976;57:1041–50.

5. James LK, Shamji MH, Walker SM, Wilson DR, Wachholz PA, Francis JN, Jacobson MR, Kimber I, Till SJ, Durham SR. Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies. J Allergy Clin Immunol. 2011;127:509–16.

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