Author:
Fernandez-Turizo Maria José,Benavidez-Zora David,Anaya-Hoyos Augusto Enrique,Portillo-Gómez Sebastian,Castro-Arias Hernán Darío
Abstract
Marfan syndrome classically presents with aortic root aneurysms. Aortic ectasia causes diverse blood flow alterations, influencing the behavior of coagulation factors and platelet activity. Heparin resistance has also been reported associated with Marfan Syndrome in a small number of patients, probably due to antithrombin III (ATIII) deficiency or various mutations. The ascending aorta and the aortic valve are replaced with prosthetic material during Bentall- de Bonno procedures. Resistance to anticoagulation during extracorporeal circulation, represents a significant challenge for both anesthesiologists and the surgical team. Resistance to heparin was observed in a patient with Marfan syndrome undergoing a Bentall procedure. ATIII concentrate was not available, and ACT did not increase despite high doses of heparin. An alternate anticoagulation approach was used successfully.
Publisher
Sociedad Colombiana de Anestesiologia y Reanimacion (SCARE)
Subject
Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine
Cited by
1 articles.
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1. Heparin;Reactions Weekly;2023-07-01