1. From the Department of Physiology and Medical Physics, Centre for Systems Medicine, and PHS Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland; NorLux Neuro-oncology Laboratory, Department of Biomedicine and Institute of Medicine, University of Bergen, Bergen, Norway; Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway; and University College Dublin, Conway Institute, Belfield, Dublin, Ireland