Chronic Cutaneous Graft-versus-Host Disease Manifesting as Calcinosis Cutis Universalis on a Background of Widespread Sclerodermatoid Changes

Abstract

Background: The cutaneous manifestations of graft-versus-host disease (GVHD) can be classified into acute and chronic forms. Acute GVHD is defined as a skin eruption that manifests within 100 days of transplantation, whereas chronic GVHD refers to cutaneous changes that appear 100 days or more posttransplantation. Objective: Although most chronic forms fall within lichenoid and sclerodermoid forms, there is a multitude of less common presentations. These include xerosis, follicular prominence, ichthyosis, and pityriasis rosea–like, eczematous, or psoriasiform lesions. Conclusions: We report a previously unreported manifestation of chronic cutaneous GVHD, specifically calcinosis cutis universalis on a background of sclerodermoid changes.