Real-World Experience with Alitretinoin in a Community Dermatology Practice Setting in Patients with Chronic Hand Dermatitis

Abstract

Background: The treatment of moderate to severe chronic hand dermatitis (CHD) has been advanced with the introduction of alitretinoin (9- cis-retinoic acid). Although clinical trial data demonstrated the efficacy and safety of alitretinoin, real-world experience is lacking in a more generalized patient population. Objective: Patients with CHD often, and unsuccessfully, attempt several therapeutic options before seeing a dermatologist. This chart review study aimed to examine the experience of using alitretinoin for CHD in a dermatology office setting. Methods: A retrospective chart review of electronic medical records was conducted of all patients prescribed alitretinoin in a community dermatology practice. Results: Alitretinoin was well tolerated in this patient population of 53 patients and showed a clinically significant reduction in disease symptoms. Conclusion: Alitretinoin was a safe and well-tolerated treatment with significant clinical improvement in our patient population. Few clinically significant laboratory abnormalities were identified, and only one patient discontinued therapy due to adverse events.