1. Division of Dermatology, Department of Medicine; Health Outcomes and PharmacoEconomics (HOPE) Research Centre, Sunnybrook Research Institute; Division of Clinical Pharmacology and Toxicology at Sunnybrook, Department of Medicine; and Department of Pharmacology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON; and International Centre for Health Innovation, Richard Ivey School of Business, Western University, London, ON.