Measuring the Severity of Topical 5-Fluorouracil Toxicity-Reference-Cited by-同舟云学术

Measuring the Severity of Topical 5-Fluorouracil Toxicity

Published:2014-07 Issue:4 Volume:18 Page:229-235
ISSN:1203-4754
Container-title:Journal of Cutaneous Medicine and Surgery
language:en
Short-container-title:J Cutan Med Surg

Author:

Korgavkar Kaveri¹,Firoz Elnaz F.¹,Xiong Michael¹,Lew Robert¹,Marcolivio Kimberly¹,Burnside Nancy¹,Dyer Robert¹,Weinstock Martin A.²¹

Affiliation:

1. From the Dermatoepidemiology Unit, Veterans Affairs Medical Center, Providence, RI; Departments of Dermatology and Epidemiology, Brown University, Providence, RI; Department of Dermatology, Rhode Island Hospital, Providence, RI; and Dermatoepidemiology Unit, Veterans Affairs Medical Center, Boston, MA

2. for the VAKCC Trial Group

Abstract

Background: Topical 5% 5-fluorouracil (5-FU) is known to cause toxicity, such as erythema, pain, and crusting/erosions. Objectives: We sought to develop a scale to measure this toxicity and test the scale for reliability. Methods: A scale was developed involving four parameters: erythema severity, percentage of face involved in erythema, crusting/erosions severity, and percentage of face involved in crusting/erosions. Thirteen raters graded 99 sets of photographs from the Veterans Affairs Keratinocyte Carcinoma Chemoprevention (VAKCC) Trial using these parameters. Results: Intraclass correlation overall for 13 raters was 0.82 (95% CI 0.77–0.86). There was no statistically significant trend in reliability by level of training in dermatology. Conclusions: This scale is a reliable method of evaluating the severity of toxicity from topical 5-fluorouracil and can be used by dermatologists and nondermatologists alike.

Publisher

SAGE Publications

Subject

Dermatology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.2310/7750.2013.13143

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